Published 2022
| Version v1
Publication
Reversibility of Central Nervous System Adverse Events in Course of Art
Creators
- Taramasso, Lucia
- Orofino, Giancarlo
- Ricci, Elena
- Menzaghi, Barbara
- De Socio, Giuseppe Vittorio
- Squillace, Nicola
- Madeddu, Giordano
- Vichi, Francesca
- Celesia, Benedetto Maurizio
- Molteni, Chiara
- Conti, Federico
- Del Puente, Filippo
- Sarchi, Eleonora
- Angioni, Goffredo
- Cascio, Antonio
- Grosso, Carmela
- Parruti, Giustino
- Di Biagio, Antonio
- Bonfanti, Paolo
Contributors
Others:
- Taramasso, Lucia
- Orofino, Giancarlo
- Ricci, Elena
- Menzaghi, Barbara
- De Socio, Giuseppe Vittorio
- Squillace, Nicola
- Madeddu, Giordano
- Vichi, Francesca
- Celesia, Benedetto Maurizio
- Molteni, Chiara
- Conti, Federico
- Del Puente, Filippo
- Sarchi, Eleonora
- Angioni, Goffredo
- Cascio, Antonio
- Grosso, Carmela
- Parruti, Giustino
- Di Biagio, Antonio
- Bonfanti, Paolo
Description
The purpose of this study is to evaluate the frequency of central nervous system adverse events (CNS-AE) on dolutegravir (DTG) and non-DTG containing ART, and their reversibility, in the observational prospective SCOLTA cohort. Factors associated with CNS-AE were estimated using a Cox proportional-hazards model. 4939 people living with HIV (PLWH) were enrolled in DTG (n = 1179) and non-DTG (n = 3760) cohorts. Sixty-six SNC-AE leading to ART discontinuation were reported, 39/1179 (3.3%) in DTG and 27/3760 (0.7%) in non-DTG cohort. PLWH naive to ART, with higher CD4 + T count and with psychiatric disorders were more likely to develop a CNS-AE. The risk was lower in non-DTG than DTG-cohort (aHR 0.33, 95% CI 0.19-0.55, p < 0.0001). One-year follow-up was available for 63/66 PLWH with CNS-AE. AE resolution was reported in 35/39 and 23/24 cases in DTG and non-DTG cohorts, respectively. The probability of AE reversibility was not different based on ART class, sex, ethnicity, CDC stage, or baseline psychiatric disorder. At the same time, a lower rate of event resolution was found in PLWH older than 50 years (p = 0.017). In conclusion, CNS-AE leading to ART discontinuation was more frequent in DTG than non-DTG treated PLWH. Most CNS-AE resolved after ART switch, similarly in both DTG and non-DTG cohorts.
Additional details
Identifiers
- URL
- http://hdl.handle.net/11567/1096565
- URN
- urn:oai:iris.unige.it:11567/1096565
Origin repository
- Origin repository
- UNIGE