Published February 5, 2021
| Version v1
Publication
Correlaciones de biomarcadores del primer trimestre con el peso fetal y con el peso materno en embarazadas con diabetes gestacional.
Contributors
Description
Given the obstetric and metabolic importance of Gestational Diabetes, we wanted to
study the correlations ofthe first trimester biomarkers with the weight ofthe fetus at 20
weeks and with that of the mother at 28 weeks of gestation for pregnant women with
and without gestational diabetes in a research carried out in primary care. This is an
observational study of cases and controls. The quantitative variables analyzed were:
PAPPA (Pregnancy Associated Plasma Protein A) (mU / ml), Betahydroxychorionic
(ngrs / ml), TSH (µUI / ml) and free T4 (ngrs / dl) at 12 weeks, fetal weight at 20 weeks
and maternal weight in kilograms at 28 weeks. As a descriptive balancing variable, we
have used the age of the pregnant woman in years. Six health centers of the Primary
Healthcare District of Seville (Spain) have been sampled. We applied simple linear
regression using the least squares method and the smoothing technique called LOESS
(Locally Weighted Scatterplot Smoothing). A finding was highlighted above all the
others, the inverse correlations and the least squares lines of the PAPP-A and TSH
variables at 12 weeks of gestation, and the correlations between fetal weight at 20
weeks with Betahydroxychorionic and with PAPPA. The most important is the first
because of the change and the magnitude of Pearson's R2 (+0.10) in pregnant women
with gestational diabetes. We have found a noticeable change in the correlation of
PAPPA with TSH in pregnant women with Gestational Diabetes. The upper confidence
interval of the Pearson correlation coefficient reaches +0. 3 . A possible
pathophysiological explanation for this correlation found in our work could be the
action ofTSH on insulin-like growth factors in human osteoblastic cells.
Additional details
Identifiers
- URL
- https://idus.us.es/handle//11441/104658
- URN
- urn:oai:idus.us.es:11441/104658