Incidence and outcome of invasive candidiasis in intensive care units (icus) in europe: Results of the eucandicu project
- Creators
- Bassetti M.
- Giacobbe D. R.
- Vena A.
- Trucchi C.
- Ansaldi F.
- Antonelli M.
- Adamkova V.
- Alicino C.
- Almyroudi M. -P.
- Atchade E.
- Azzini A. M.
- Carannante N.
- Carnelutti A.
- Corcione S.
- Cortegiani A.
- Dimopoulos G.
- Dubler S.
- Garcia-Garmendia J. L.
- Girardis M.
- Cornely O. A.
- Ianniruberto S.
- Kullberg B. J.
- Lagrou K.
- Le Bihan C.
- Luzzati R.
- Malbrain M. L. N. G.
- Merelli M.
- Marques A. J.
- Martin-Loeches I.
- Mesini A.
- Paiva J. -A.
- Peghin M.
- Raineri S. M.
- Rautemaa-Richardson R.
- Schouten J.
- Brugnaro P.
- Spapen H.
- Tasioudis P.
- Timsit J. -F.
- Tisa V.
- Tumbarello M.
- Van Den Berg C. H. S. B.
- Veber B.
- Venditti M.
- Voiriot G.
- Wauters J.
- Montravers P.
- Others:
- Bassetti, M.
- Giacobbe, D. R.
- Vena, A.
- Trucchi, C.
- Ansaldi, F.
- Antonelli, M.
- Adamkova, V.
- Alicino, C.
- Almyroudi, M. -P.
- Atchade, E.
- Azzini, A. M.
- Carannante, N.
- Carnelutti, A.
- Corcione, S.
- Cortegiani, A.
- Dimopoulos, G.
- Dubler, S.
- Garcia-Garmendia, J. L.
- Girardis, M.
- Cornely, O. A.
- Ianniruberto, S.
- Kullberg, B. J.
- Lagrou, K.
- Le Bihan, C.
- Luzzati, R.
- Malbrain, M. L. N. G.
- Merelli, M.
- Marques, A. J.
- Martin-Loeches, I.
- Mesini, A.
- Paiva, J. -A.
- Peghin, M.
- Raineri, S. M.
- Rautemaa-Richardson, R.
- Schouten, J.
- Brugnaro, P.
- Spapen, H.
- Tasioudis, P.
- Timsit, J. -F.
- Tisa, V.
- Tumbarello, M.
- Van Den Berg, C. H. S. B.
- Veber, B.
- Venditti, M.
- Voiriot, G.
- Wauters, J.
- Montravers, P.
Citation
Description
Background: The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods: A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). Results: During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02-1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31-8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04-1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24-3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. Conclusions: The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.
Additional details
- URL
- http://hdl.handle.net/11567/954016
- URN
- urn:oai:iris.unige.it:11567/954016
- Origin repository
- UNIGE