Development of 2-deoxystreptamine–nucleobase conjugates for the inhibition of oncogenic miRNA production

Creators: Tran, Thi Phuong Anh; Poulet, Sylvain; Pernak, Mélanie; Rayar, Anita; Azoulay, Stéphane; Di Giorgio, Audrey; Duca, Maria

Others:: Institut de Chimie de Nice (ICN) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA); Université Côte d'Azur (UCA)

Description

2-deoxystreptamine (2-DOS) conjugates with artificial nucleobases were designed and synthesized to inhibit pre-miR-372 processing into oncogenic miRNA and were discovered to be promising inhibitors when compared to their neomycin counterpart.

Abstract

International audience

Development of 2-deoxystreptamine–nucleobase conjugates for the inhibition of oncogenic miRNA production

Description

Abstract

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