Published 2020 | Version v1
Publication

Virological response and retention in care according to time of starting ART in Italy: data from the Icona Foundation Study cohort

A d'Arminio Monforte
A Antinori
M Andreoni
A Castagna
F Castelli
R Cauda
G Di Perri
M Galli
R Iardino
G Ippolito
A Lazzarin
G C Marchetti
G Rezza
F von Schloesser
P Viale
A d'Arminio Monforte
A Antinori
A Castagna
F Ceccherini-Silberstein
A Cozzi-Lepri
E Girardi
S Lo Caputo
C Mussini
M Puoti
C F Perno
A Antinori
F Bai
C Balotta
A Bandera
S Bonora
M Borderi
A Calcagno
A Capetti
M R Capobianchi
A Castagna
F Ceccherini-Silberstein
S Cicalini
A Cingolani
P Cinque
A Cozzi-Lepri
A d'Arminio Monforte
A De Luca
A Di Biagio
E Girardi
N Gianotti
A Gori
G Guaraldi
G Lapadula
M Lichtner
S Lo Caputo
G Madeddu
F Maggiolo
G Marchetti
L Monno
C Mussini
S Nozza
C F Perno
C Pinnetti
M Puoti
E Quiros Roldan
R Rossotti
S Rusconi
M M Santoro
A Saracino
L Sarmati
A Cozzi-Lepri
I Fanti
L Galli
P Lorenzini
A Rodano'
M Macchia
A Tavelli
F Carletti
S Carrara
A Di Caro
S Graziano
F Petroni
G Prota
S Truffa
A Giacometti
A Costantini
V Barocci
G Angarano
L Monno
E Milano
F Maggiolo
C Suardi
P Viale
V Donati
G Verucchi
F Castelnuovo
C Minardi
E Quiros Roldan
B Menzaghi
C Abeli
B Cacopardo
B Celesia
J Vecchiet
K Falasca
A Pan
S Lorenzotti
L Sighinolfi
D Segala
P Blanc
F Vichi
G Cassola
C Viscoli
A Alessandrini
N Bobbio
G Mazzarello
M Lichtner
L Fondaco
P Bonfanti
C Molteni
A Chiodera
P Milini
G Nunnari
G Pellicanò
A d'Arminio Monforte
M Galli
A Lazzarin
G Rizzardini
M Puoti
A Castagna
E S Cannizzo
M C Moioli
R Piolini
D Bernacchia
S Salpietro
C Tincati
C Mussini
C Puzzolante
C Migliorino
G Lapadula
V Sangiovanni
G Borgia
V Esposito
G Di Flumeri
I Gentile
V Rizzo
A M Cattelan
S Marinello
A Cascio
M Trizzino
D Francisci
E Schiaroli
G Parruti
F Sozio
G Magnani
M A Ursitti
M Andreoni
A Antinori
R Cauda
A Cristaudo
V Vullo
R Acinapura
D Moschese
M Capozzi
A Mondi
A Cingolani
M Rivano Capparuccia
G Iaiani
A Latini
R Gagliardini
M M Plazzi
G De Girolamo
A Vergori
M Cecchetto
F Viviani
G Madeddu
A De Vito
B Rossetti
F Montagnani
A Franco
R Fontana Del Vecchio
C Di Giuli
P Caramello
G Di Perri
S Bonora
G C Orofino
M Sciandra
M Bassetti
A Londero
V Manfrin
G Battagin
G Starnini
A Ialungo
Others:
d'Arminio Monforte, A
Antinori, A
Andreoni, M
Castagna, A
Castelli, F
Cauda, R
Di Perri, G
Galli, M
Iardino, R
Ippolito, G
Lazzarin, A
C Marchetti, G
Rezza, G
von Schloesser, F
Viale, P
d'Arminio Monforte, A
Antinori, A
Castagna, A
Ceccherini-Silberstein, F
Cozzi-Lepri, A
Girardi, E
Lo Caputo, S
Mussini, C
Puoti, M
F Perno, C
Antinori, A
Bai, F
Balotta, C
Bandera, A
Bonora, S
Borderi, M
Calcagno, A
Capetti, A
R Capobianchi, M
Castagna, A
Ceccherini-Silberstein, F
Cicalini, S
Cingolani, A
Cinque, P
Cozzi-Lepri, A
d'Arminio Monforte, A
De Luca, A
DI BIAGIO, Antonio
Girardi, E
Gianotti, N
Gori, A
Guaraldi, G
Lapadula, G
Lichtner, M
Lo Caputo, S
Madeddu, G
Maggiolo, F
Marchetti, G
Monno, L
Mussini, C
Nozza, S
F Perno, C
Pinnetti, C
Puoti, M
Quiros Roldan, E
Rossotti, R
Rusconi, S
M Santoro, M
Saracino, A
Sarmati, L
Cozzi-Lepri, A
Fanti, I
Galli, L
Lorenzini, P
Rodano', A
Macchia, M
Tavelli, A
Carletti, F
Carrara, S
Di Caro, A
Graziano, S
Petroni, F
Prota, G
Truffa, S
Giacometti, A
Costantini, A
Barocci, V
Angarano, G
Monno, L
Milano, E
Maggiolo, F
Suardi, C
Viale, P
Donati, V
Verucchi, G
Castelnuovo, F
Minardi, C
Quiros Roldan, E
Menzaghi, B
Abeli, C
Cacopardo, B
Celesia, B
Vecchiet, J
Falasca, K
Pan, A
Lorenzotti, S
Sighinolfi, L
Segala, D
Blanc, P
Vichi, F
Cassola, G
Viscoli, C
Alessandrini, A
Bobbio, N
Mazzarello, G
Lichtner, M
Fondaco, L
Bonfanti, P
Molteni, C
Chiodera, A
Milini, P
Nunnari, G
Pellicanò, G
d'Arminio Monforte, A
Galli, M
Lazzarin, A
Rizzardini, G
Puoti, M
Castagna, A
S Cannizzo, E
C Moioli, M
Piolini, R
Bernacchia, D
Salpietro, S
Tincati, C
Mussini, C
Puzzolante, C
Migliorino, C
Lapadula, G
Sangiovanni, V
Borgia, G
Esposito, V
Di Flumeri, G
Gentile, I
Rizzo, V
M Cattelan, A
Marinello, S
Cascio, A
Trizzino, M
Francisci, D
Schiaroli, E
Parruti, G
Sozio, F
Magnani, G
A Ursitti, M
Andreoni, M
Antinori, A
Cauda, R
Cristaudo, A
Vullo, V
Acinapura, R
Moschese, D
Capozzi, M
Mondi, A
Cingolani, A
Rivano Capparuccia, M
Iaiani, G
Latini, A
Gagliardini, R
M Plazzi, M
De Girolamo, G
Vergori, A
Cecchetto, M
Viviani, F
Madeddu, G
De Vito, A
Rossetti, B
Montagnani, F
Franco, A
Fontana Del Vecchio, R
Di Giuli, C
Caramello, P
Di Perri, G
Bonora, S
C Orofino, G
Sciandra, M
Bassetti, M
Londero, A
Manfrin, V
Battagin, G
Starnini, G
Ialungo, A

Citation

An error occurred while generating the citation.

Description

OBJECTIVES: To describe: (i) factors associated with rapid and delayed ART initiation; (ii) rates of 12 week virological response; and (iii) virologically controlled retention in care by 1 year from ART initiation according to timing of start in a real-life setting. METHODS: All individuals in the Icona cohort diagnosed with HIV in 2016-17 who initiated ART were grouped according to the time between HIV diagnosis and ART initiation: Group 1, ≤7 days; Group 2, 8-14 days; Group 3, 15-30 days; Group 4, 31-120 days; and Group 5, >120 days. Multivariable logistic regression models were used to identify factors associated with: (i) the probability of rapid (Group 1) and very delayed (Group 5) ART initiation; (ii) the 12 week virological response (by a modified snapshot algorithm); and (iii) the probability of retention in care at 1 year (on ART with HIV-RNA <50 copies/mL). RESULTS: A total of 1247 individuals were included [82 (6.6%) in Group 1, 115 (9.2%) in Group 2, 267 (21.4%) in Group 3, 641 (51.4%) in Group 4 and 142 (11.4%) in Group 5]. Main predictors of rapid ART start (Group 1) were low CD4 cell count and high HIV-RNA at first contact with the infectious diseases centre. There was no association between probability of virological response and timing of ART initiation. Overall, 90% of individuals remained on ART after 1 year, 91% with undetectable HIV-RNA. Participants of Italian nationality, those with higher CD4 cell count and lower HIV-RNA at ART initiation were more likely to be retained in care after 1 year. CONCLUSIONS: In our high-income observational setting, we did not observe differences in the 1 year rate of virological response and retention in care according to timing of ART initiation.

Additional details

Created:
April 14, 2023
Modified:
November 30, 2023