Breast cancer mammospheres secrete Adrenomedullin to induce lipolysis and browning of adjacent adipocytes

Creators: Paré, Martin; Darini, Cédric; Yao, Xi; Chignon-Sicard, Bérengère; Rekima, Samah; Lachambre, Simon; Virolle, Virginie; Aguilar-Mahecha, Adriana; Basik, Mark; Dani, Christian; Ladoux, Annie

Others:: Institut de Biologie Valrose (IBV) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA); Segal Cancer Centre ; Lady Davis Institute; Université Côte d'Azur (UCA); Division of Experimental Medicine [Montréal, QC, Canada] (Department of Medicine) ; McGill University Health Center [Montreal] (MUHC)

Description

Cancer cells cooperate with cells that compose their environment to promote tumor growth and invasion. Among them, adipocytes provide lipids used as a source of energy by cancer cells and adipokines that contribute to tumor expansion. Mechanisms supporting the dynamic interactions between cancer cells and stromal adipocytes, however, remain unclear.

Abstract

International audience

Breast cancer mammospheres secrete Adrenomedullin to induce lipolysis and browning of adjacent adipocytes

Description

Abstract

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