Published 2021
| Version v1
Publication
MMP-2 knockdown blunts age-dependent carotid stiffness by decreasing elastin degradation and augmenting eNOS activation
Creators
- Diaz-Canestro, Candela
- Puspitasari, Yustina M
- Liberale, Luca
- Guzik, Tomasz J
- Flammer, Andreas J
- Bonetti, Nicole R
- Wüst, Patricia
- Costantino, Sarah
- Paneni, Francesco
- Akhmedov, Alexander
- Varga, Zsuzsanna
- Ministrini, Stefano
- Beer, Jürg H
- Ruschitzka, Frank
- Hermann, Matthias
- Lüscher, Thomas F
- Sudano, Isabella
- Camici, Giovanni G
Contributors
Others:
- Diaz-Canestro, Candela
- Puspitasari, Yustina M
- Liberale, Luca
- Guzik, Tomasz J
- Flammer, Andreas J
- Bonetti, Nicole R
- Wüst, Patricia
- Costantino, Sarah
- Paneni, Francesco
- Akhmedov, Alexander
- Varga, Zsuzsanna
- Ministrini, Stefano
- Beer, Jürg H
- Ruschitzka, Frank
- Hermann, Matthia
- Lüscher, Thomas F
- Sudano, Isabella
- Camici, Giovanni G
Description
Arterial stiffness is a hallmark of vascular aging that precedes and strongly predicts the development of cardiovascular diseases. Age-dependent stiffening of large elastic arteries is primarily attributed to increased levels of matrix metalloproteinase-2 (MMP-2). However, the mechanistic link between age-dependent arterial stiffness and MMP-2 remains unclear. Thus, we aimed to investigate the efficacy of MMP-2 knockdown using small interfering RNA (siRNA) on age-dependent arterial stiffness.
Additional details
Identifiers
- URL
- http://hdl.handle.net/11567/1059338
- URN
- urn:oai:iris.unige.it:11567/1059338
Origin repository
- Origin repository
- UNIGE