Published September 2, 2021 | Version v1
Publication Metadata-only

A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin

Gómez González, Belén
Sessa, Gaetana
Carreira, Aura
Aguilera López, Andrés
Other:
Universidad de Sevilla. Departamento de Genética

Description

In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair. Interestingly, BRCA2–DDX5 interaction is impaired in cells expressing the BRCA2T207A missense variant found in breast cancer patients.

Additional details

Identifiers Origin repository
Created:
December 4, 2022
Modified:
November 30, 2023