Published 2009
| Version v1
Publication
Clinical course of classic Kaposi's sarcoma in HIV-negative patients treated with the HIV protease inhibitor indinavir
- Creators
- Correction Monini P.
- Sgadari C.
- Grosso M. G.
- Bellino S.
- Di Biagio A.
- Toschi E.
- Bacigalupo I.
- Sabbatucci M.
- Cencioni G.
- Salvi E.
- Leone P.
- Ensoli B.
- Barillari G.
- Moracci G.
- Carratelli L.
- Gatti G.
- Brambilla L.
- Brambati M.
- Ferrucci S.
- De Pita O.
- Pilla M. A.
- Di Carlo A.
- Giuliani M.
- Cottoni F.
- Cuccuru M. A.
- Calvieri S.
- Clerico R.
- Potenza C.
- Tirelli U.
- Simonelli C.
- Martellotta F.
- Strumia R.
- Borghi A.
- Del Giacco S.
- Moi L.
- Piludu G.
- Sirianni M. C.
- Campagna M.
- Sarmati L.
- Andreoni M.
- Bianchini G.
- Sheldon J.
- Milzer J.
- Schulz T.
- Others:
- Correction Monini, P.
- Sgadari, C.
- Grosso, M. G.
- Bellino, S.
- Di Biagio, A.
- Toschi, E.
- Bacigalupo, I.
- Sabbatucci, M.
- Cencioni, G.
- Salvi, E.
- Leone, P.
- Ensoli, B.
- Barillari, G.
- Moracci, G.
- Carratelli, L.
- Gatti, G.
- Brambilla, L.
- Brambati, M.
- Ferrucci, S.
- De Pita, O.
- Pilla, M. A.
- Di Carlo, A.
- Giuliani, M.
- Cottoni, F.
- Cuccuru, M. A.
- Calvieri, S.
- Clerico, R.
- Potenza, C.
- Tirelli, U.
- Simonelli, C.
- Martellotta, F.
- Strumia, R.
- Borghi, A.
- Del Giacco, S.
- Moi, L.
- Piludu, G.
- Sirianni, M. C.
- Campagna, M.
- Sarmati, L.
- Andreoni, M.
- Bianchini, G.
- Sheldon, J.
- Milzer, J.
- Schulz, T.
Description
HIV protease inhibitors have been shown to exert antiangiogenic and antitumor actions independently from their antiretroviral effect. Based on these studies, HIV-seronegative patients with classic Kaposi's sarcoma were treated with indinavir and followed for clinical evolution, drug pharmacokinetics and Kaposi's sarcoma biomarkers. A favorable clinical course was associated with high drug plasma levels, reduced production of basic fibroblast growth factor, lower numbers of circulating endothelial cells, and a decrease in antibody titers against human herpesvirus 8.
Additional details
- URL
- http://hdl.handle.net/11567/992945
- URN
- urn:oai:iris.unige.it:11567/992945
- Origin repository
- UNIGE