Published November 3, 2020
| Version v1
Journal article
High Prevalence of Acquired Thrombophilia Without Prognosis Value in Patients With Coronavirus Disease 2019
Creators
- Ferrari, Emile
- Sartre, Benjamin
- Squara, Fabien
- Contenti, Julie
- Occelli, Celine
- Lemoel, Fabien
- Levraut, Jacques
- Doyen, Denis
- Dellamonica, Jean
- Mondain, Veronique
- Chirio, David
- Risso, Karine
- Cua, Eric
- Orban, Jean Christophe
- Ichai, Carole
- Labbaoui, Mohamed
- Mossaz, Baptiste
- Moceri, Pamela
- Appert‐flory, Anny
- Fischer, Florence
- Toulon, Pierre
Contributors
Others:
- Hôpital Pasteur [Nice] (CHU)
- Université Nice Sophia Antipolis - Faculté de Médecine (UNS UFR Médecine) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)
- Centre Hospitalier Universitaire de Nice (CHU Nice)
- Service de Réanimation médico-chirurgicale [Nice] ; Hôpital Saint-Roch [Nice]
- Centre méditerranéen de médecine moléculaire (C3M) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)
- Service d'infectiologie [CHU Nice] ; Centre Hospitalier Universitaire de Nice (CHU Nice)
Description
BackgroundRecent literature reports a strong thrombotic tendency in patients hospitalized for a coronavirus disease 2019 (COVID‐19) infection. This characteristic is unusual and seems specific to COVID‐19 infections, especially in their severe form. Viral infections can trigger acquired thrombophilia, which can then lead to thrombotic complications. We investigate for the presence of acquired thrombophilia, which could participate in this phenomenon, and report its prevalence. We also wonder if these thrombophilias participate in the bad prognosis of severe COVID‐19 infections.Methods and ResultsIn 89 consecutive patients hospitalized for COVID‐19 infection, we found a 20% prevalence of PS (protein S) deficiency and a high (ie, 72%) prevalence of antiphospholipid antibodies: mainly lupus anticoagulant. The presence of PS deficiency or antiphospholipid antibodies was not linked with a prolonged activated partial thromboplastin time nor with D‐dimer, fibrinogen, or CRP (C‐reactive protein) concentrations. These coagulation abnormalities are also not linked with thrombotic clinical events occurring during hospitalization nor with mortality.ConclusionsWe assess a high prevalence of positive tests detecting thrombophilia in COVID‐19 infections. However, in our series, these acquired thrombophilias are not correlated with the severity of the disease nor with the occurrence of thrombotic events. Albeit the strong thrombotic tendency in COVID‐19 infections, the presence of frequent acquired thrombophilia may be part of the inflammation storm of COVID‐19 and should not systematically modify our strategy on prophylactic anticoagulant treatment, which is already revised upwards in this pathological condition.
Abstract
International audienceAdditional details
Identifiers
- URL
- https://hal.sorbonne-universite.fr/hal-03099555
- URN
- urn:oai:HAL:hal-03099555v1
Origin repository
- Origin repository
- UNICA