Published 2010
| Version v1
Publication
Inhibition of presynaptic release-facilitatory kainate autoreceptors by extracellular cyclic GMP
- Creators
- CERVETTO, CHIARA
- MAURA, GUIDO
- MARCOLI, MANUELA
Description
We found that both α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate autoreceptors were present on the glutamate-releasing terminals of cerebellar parallel/climbing fibers and that they functioned as facilitatory autoreceptors. Extracellular cGMP inhibited the neurotransmitter release evoked by presynaptic kainate receptor activation; the inhibitory effect of extracellular cGMP was selective for the kainate autoreceptor-mediated response and did not affect the AMPA autoreceptor-mediated response. Endogenously synthesized cGMP might be the physiological source for the extracellular cGMP modulating the response to kainate autoreceptor activation
Additional details
- URL
- http://hdl.handle.net/11567/265639
- URN
- urn:oai:iris.unige.it:11567/265639
- Origin repository
- UNIGE