Published 2012
| Version v1
Publication
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation
Description
In pursuing our research on some 2,4-diamino-benzopyranopyrimidines and 2-amino-5,6-dihydrobenzo[
h]quinazolines, previously reported as antiplatelet and analgesic/anti-inflammatory agents
respectively, we designed and synthesized a new series of 5,6-dihydrobenzo[h]quinazoline 2,4-diamino
substituted. The insertion of amino substituents at positions 2 and 4 of the benzoquinazoline scaffold
resulted in compounds endowed with a potent ASA-like antiplatelet activity, combined with an antiinflammatory
activity comparable, in some cases, to that of indomethacin, used as a reference drug.
Additional details
Identifiers
- URL
- http://hdl.handle.net/11567/376393
- URN
- urn:oai:iris.unige.it:11567/376393
Origin repository
- Origin repository
- UNIGE