Published March 26, 2020
| Version v1
Publication
Biomarkers predictive value for early diagnosis of Stroke- Associated Pneumonia.
Description
To confirm the diagnostic accuracy of candidate biomarkers in stroke-associ-
ated pneumonia (SAP), we prospectively enrolled ischemic stroke patients with
NIHSS ≥ 10 on admission from March-2016 to August-2017. Blood samples
were collected at baseline, 24 and 48 h after stroke onset. Biomarkers (MR-
proADM, suPAR, SAA) were determined by immunoassays. Regarding
biomarkers, MR-proADM at 24 h (P = 0.04) and both suPAR and SAA at 48 h
(P = 0.036 and P = 0.057) were associated with pneumonia. The combination
of SAA > 25.15 mg/dL and suPAR> 3.14 ng/mL at 48 h had 80% sensitivity
and 95.8% specificity when both biomarkers were above the cut-off. The evalu-
ated biomarkers represent promising tools to be evaluated in future large,
prospective studies on SAP. An accurate SAP diagnosis by thorax CT might
help to reduce variability in such studies.
Additional details
Identifiers
- URL
- https://idus.us.es/handle//11441/94601
- URN
- urn:oai:idus.us.es:11441/94601