Primary Progressive Aphasia in the Network of French Alzheimer Plan Memory Centers
- Creators
- Magnin, Eloi
- Démonet, Jean-François
- Wallon, David
- Dumurgier, Julien
- Troussière, Anne-Cécile
- Jager, Alain
- Duron, Emmanuelle
- Gabelle, Audrey
- de La Sayette, Vincent
- Volpe-Gillot, Lisette
- Tio, Gregory
- Evain, Sarah
- Boutoleau-Bretonnière, Claire
- Enderle, Adeline
- Mouton-Liger, François
- Robert, Philippe
- Hannequin, Didier
- Pasquier, Florence
- Hugon, Jacques
- Paquet, Claire
- Collaborators, Eplm
- Others:
- Centre Mémoire de Ressources et de Recherche [CHRU de Besançon] (CMRR) ; Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Hôpital Saint-Jacques [CHRU de Besançon]
- Service de neurologie [Rouen] ; CHU Rouen ; Normandie Université (NU)-Normandie Université (NU)
- Génétique du cancer et des maladies neuropsychiatriques (GMFC) ; Université de Rouen Normandie (UNIROUEN) ; Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Centre Mémoire de Ressources et de Recherche Paris Nord Ile-de-France (CMRR) ; Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
- Biomarqueurs CArdioNeuroVASCulaires (BioCANVAS) ; Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)
- Centre Mémoire de Ressources et de Recherche - CMRR [CHRU Lille]
- Centre de Neurologie [Thionville] ; Centre hospitalier régional Metz-Thionville (CHR Metz-Thionville)
- Centre de Mémoire de Ressources et de Recherche [Paris Broca] ; AP-HP - Hôpital Broca [Paris]
- Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
- Cellules souches normales et cancéreuses ; Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
- CHU Caen ; Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)
- Groupe Hospitalier Paris Saint Joseph
- Centre Mémoire de Ressources et de Recherche [CHU de Nantes] ; Centre hospitalier universitaire de Nantes (CHU Nantes)
- Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
- Centre Mémoire de Ressources et de Recherche [Nice] (CMRR Nice) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Université Côte d'Azur (UCA)
- Cognition Behaviour Technology (CobTek) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Institut Claude Pompidou [Nice] (ICP - Nice)-Université Côte d'Azur (UCA)
Description
BACKGROUND:Few demographical data about primary progressive aphasia (PPA) are available, and most knowledge regarding PPA is based on tertiary centers' results.OBJECTIVE:Our aims were to describe demographical characteristics of the PPA population in a large sample of PPA patients from the network of French Alzheimer plan memory centers (Sample 1), and to describe the stratification of cerebrospinal fluid (CSF) biomarkers in two different samples of PPA patients (Samples 2 and 3).METHODS:All registered PPA patients in the French Alzheimer's disease (AD) databank (Sample 1: n = 2,035) and a subsample (Sample 2: n = 65) derived from a multicentric prospective cohort with CSF biomarker analysis were analyzed. A multicentric retrospective cohort from language expert tertiary centers (Sample 3: n = 97) with CSF biomarker analysis was added. Sample 3 was added to replicate the CSF results of the Sample 2 and to evaluate repartition of AD pathology in the three variant of PPA according to the latest classification.RESULTS:Non-Fluent/Agrammatic, Logopenic, and Unclassifiable PPA patients (NF/A-Logo-Unclass PPA) were older and more frequent than Semantic PPA patients (2.2 versus 0.8/100,000 inhabitants; p < 0.00001). Male predominance occurred after the age of 80 (p < 0.00001). A higher level of education was observed in the PPA population compared to a typical amnesic AD group. No demographical significant difference between PPA due to AD and not due to AD was observed. The Logopenic variant was most frequent with 85% of AD CSF biomarker profiles (35% in NF/A PPA; 20% in Semantic PPA).CONCLUSION:PPA occurs also in an elderly population, especially in male patients over 80. CSF biomarkers are useful to stratify PPA. The epidemiology of PPA should be further investigated to confirm gender and cognitive reserve role in PPA to better understand the factors and mechanisms leading to this language-predominant deficit during neurodegenerative diseases.
Abstract
International audience
Additional details
- URL
- https://hal.archives-ouvertes.fr/hal-01824840
- URN
- urn:oai:HAL:hal-01824840v1
- Origin repository
- UNICA