Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development

Creators: Hellstrom A.; Ley D.; Hansen-Pupp I.; Hallberg B.; Lofqvist C.; Van Marter L.; Van Weissenbruch M.; Ramenghi L. A.; Beardsall K.; Dunger D.; Hard A. -L.; Smith L. E. H.

Others:: Hellstrom, A.; Ley, D.; Hansen-Pupp, I.; Hallberg, B.; Lofqvist, C.; Van Marter, L.; Van Weissenbruch, M.; Ramenghi, L. A.; Beardsall, K.; Dunger, D.; Hard, A. -L.; Smith, L. E. H.

Description

Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities. Conclusion There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants.

Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development

Description

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