Cutting Edge: Lectin-Like Transcript 1 Is a Ligand for the CD161 Receptor 1
- Others:
- Institut de pharmacologie moléculaire et cellulaire (IPMC) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)
- Etablissement Français du Sang [Nantes]
Description
Human NK cells and subsets of T cells or NKT cells express the orphan C-type lectin receptor CD161 (NKR-P1A) of unknown function. In contrast to rodents that possess several NKR-P1 genes coding for either activating or inhibitory receptors, the nature of signals delivered by the single human NKR-P1A receptor is still to be clarified. In this article, we show that the lectin-like transcript 1 (LLT1) molecule is a ligand for the CD161 receptor. Engagement of CD161 on NK cells with LLT1 expressed on target cells inhibited NK cell-mediated cytotoxicity and IFN-␥ secretion. Conversely, LLT1/CD161 interaction in the presence of a TCR signal enhanced IFN-␥ production by T cells. These findings identify a novel ligand/receptor pair that differentially regulate NK and T cell functions.
Abstract
International audience
Additional details
- URL
- https://www.hal.inserm.fr/inserm-03346776
- URN
- urn:oai:HAL:inserm-03346776v1
- Origin repository
- UNICA