Alginate versus npwt in the preparation of surgical excisions for an stsg: atec trial
- Creators
- Casanova, Dominique
- Guerreschi, Pierre
- Sinna, Raphael
- Bertheuil, Nicolas
- Philandrianos, Cecile
- Chignon-Sicard, Berengere
- Duteille, Franck
- Atlan, Michael
- Rousseau, Pascal
- Chatellier, Gilles
- Boucher, Fabien
- Pham Dang, Nathalie
- Cambon-Binder, Adeline
- Michot, Audrey
- Pluvy, Isabelle
- Seigle-Murandi, Frederic
- Hu, Weiguo
- Revol, Marc
- Others:
- Hôpital de la Conception [CHU - APHM] (LA CONCEPTION)
- Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 (MBLC - ADDS) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [CHU Lille] (CHRU Lille) ; Université de Lille-Université de Lille
- CHU Amiens-Picardie
- Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
- Université Côte d'Azur (UniCA)
- Centre hospitalier universitaire de Nantes (CHU Nantes)
- CHU Tenon [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
- Centre Hospitalier Universitaire d'Angers (CHU Angers) ; PRES Université Nantes Angers Le Mans (UNAM)
- CIC - HEGP (CIC 1418) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)
- CHU Clermont-Ferrand
- CHU Saint-Antoine [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
- Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)
- Centre Hospitalier Universitaire [Strasbourg] (CHU Strasbourg)
- Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)
Description
A calcium alginate dressing (ALGINATE) and negative pressure wound therapy (NPWT) are frequently used to treat wounds which heal by secondary intention. This trial compared the healing efficacy and safety of these 2 treatments.This randomized, non-inferiority trial enrolled patients who underwent skin excision (>30 cm2ALGINATE and NPWT were applied to 47 and 48 patients, respectively. The mean time to optimal granulation was 19.98 days (95% CI, 17.7-22.3) with ALGINATE and 20.54 (95% CI, 17.6-23.5) with NPWT. Between group difference was -0.56 days (95% CI -4.22 to 3.10). The non-inferiority of ALGINATE versus NPWT was demonstrated. No AE related to the treatment occurred with ALGINATE versus 14 AEs with NPWT. There was no difference in the impact of the treatments on the patient's daily life.This trial demonstrates that ALGINATE has a similar healing efficacy to that of NPWT and that is markedly better with regard to patient safety.
Abstract
International audience
Additional details
- URL
- https://hal.univ-lille.fr/hal-04474376
- URN
- urn:oai:HAL:hal-04474376v1
- Origin repository
- UNICA