Towards Validating Structural Connectivity in the Human Language System: An Intraoperative Cortico-Cortical Stimulation Experiment

Creators: Filipiak, Patryk; Almairac, Fabien; Papadopoulo, Théodore; Fontaine, Denys; Mondot, Lydiane; Chanalet, Stéphane; Descoteaux, Maxime; Deriche, Rachid; Clerc, Maureen; Wassermann, Demian

Others:: Computational Imaging of the Central Nervous System (ATHENA) ; Inria Sophia Antipolis - Méditerranée (CRISAM) ; Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria); COMUE Université Côte d'Azur (2015-2019) (COMUE UCA); Département de Neurochirurgie [Hôpital Pasteur de Nice] ; Hôpital Pasteur [Nice] (CHU); Hôpital Pasteur [Nice] (CHU); Centre Hospitalier Universitaire de Nice (CHU Nice); Sherbrooke Connectivity Imaging Lab [Sherbrooke] (SCIL) ; Département d'informatique [Sherbrooke] (UdeS) ; Faculté des sciences [Sherbrooke] (UdeS) ; Université de Sherbrooke (UdeS)-Université de Sherbrooke (UdeS)-Faculté des sciences [Sherbrooke] (UdeS) ; Université de Sherbrooke (UdeS)-Université de Sherbrooke (UdeS); Inria Sophia Antipolis - Méditerranée (CRISAM) ; Institut National de Recherche en Informatique et en Automatique (Inria); Commissariat à l'énergie atomique et aux énergies alternatives (CEA); ANR-16-NEUC-0002,NeuroRef,Building Normative Atlases of Diffusion MRI to Identify Subject-Specific Neuroimaging Abnormalities in Brain Trauma and Post-Traumatic Stress(2016)

Description

We aimed to validate structural connectivity measures based on diffusion MRI with Electrical Stimulation (ES) of the human brain cortex. For this, we combined white matter fiber tractography with propagation of Cortico-Cortical Evoked Potentials (CCEPs) induced by in-trasurgical ES in the language system of brain tumor patients. Our results showed high correlation (Pearson's coefficient 0.5-0.9) between delays of CCEPs and pathways connecting stimulation sites with recording electrodes. Our approach outperformed earlier study based on Diffusion Tensor Imaging. This potentially indicates that probabilistic tractogra-phy is an effective tool to quantify cortico-cortical communication non-invasively.

Abstract

International audience

Towards Validating Structural Connectivity in the Human Language System: An Intraoperative Cortico-Cortical Stimulation Experiment

Description

Abstract

Additional details