Published 2003
| Version v1
Publication
Cellular and molecular basis of natural killer and natural killer-like activity.
Description
The capability of killing various tumors or cells infected by certain viruses is a property shared by natural killer (NK) cells and by a subset of cytolytic T lymphocytes (CTLs) termed NK-CTL. Recent analysis of the molecular basis in these phenomena, however, revealed rather different molecular mechanisms. Thus, while NK cell cytotoxicity is regulated by a complex balance between activating signals (delivered by non HLA-class I-specific triggering receptors) and inhibitory signals (delivered by HLA-class I-specific receptors) the effector function of NK-CTL reflects the TCR-mediated recognition of the poorly polymorphic HLA-E.
Additional details
- URL
- http://hdl.handle.net/11567/214000
- URN
- urn:oai:iris.unige.it:11567/214000
- Origin repository
- UNIGE