PD-L1 in small bowel adenocarcinoma is associated with etiology and tumor-infiltrating lymphocytes, in addition to microsatellite instability
- Creators
- Giuffrida P.
- Arpa G.
- Grillo F.
- Klersy C.
- Sampietro G.
- Ardizzone S.
- Fociani P.
- Fiocca R.
- Latella G.
- Sessa F.
- D'Errico A.
- Malvi D.
- Mescoli C.
- Rugge M.
- Nesi G.
- Ferrero S.
- Furlan D.
- Poggioli G.
- Rizzello F.
- Macciomei M. C.
- Santini D.
- Volta U.
- De Giorgio R.
- Caio G.
- Calabro A.
- Ciacci C.
- D'Armiento M.
- Rizzo A.
- Solina G.
- Martino M.
- Tonelli F.
- Villanacci V.
- Cannizzaro R.
- Canzonieri V.
- Florena A. M.
- Biancone L.
- Monteleone G.
- Caronna R.
- Ciardi A.
- Elli L.
- Caprioli F.
- Vecchi M.
- D'Inca R.
- Zingone F.
- D'Odorico A.
- Vincenzo Lenti M.
- Oreggia B.
- Reggiani Bonetti L.
- Astegiano M.
- Biletta E.
- Cantoro L.
- Giannone A. G.
- Orlandi A.
- Papi C.
- Perfetti V.
- Quaquarini E.
- Sandri G.
- Silano M.
- Usai P.
- Barresi V.
- Ciccocioppo R.
- Luinetti O.
- Pedrazzoli P.
- Pietrabissa A.
- Viglio A.
- Paulli M.
- Corazza G. R.
- Solcia E.
- Vanoli A.
- Di Sabatino A.
- Others:
- Giuffrida, P.
- Arpa, G.
- Grillo, F.
- Klersy, C.
- Sampietro, G.
- Ardizzone, S.
- Fociani, P.
- Fiocca, R.
- Latella, G.
- Sessa, F.
- D'Errico, A.
- Malvi, D.
- Mescoli, C.
- Rugge, M.
- Nesi, G.
- Ferrero, S.
- Furlan, D.
- Poggioli, G.
- Rizzello, F.
- Macciomei, M. C.
- Santini, D.
- Volta, U.
- De Giorgio, R.
- Caio, G.
- Calabro, A.
- Ciacci, C.
- D'Armiento, M.
- Rizzo, A.
- Solina, G.
- Martino, M.
- Tonelli, F.
- Villanacci, V.
- Cannizzaro, R.
- Canzonieri, V.
- Florena, A. M.
- Biancone, L.
- Monteleone, G.
- Caronna, R.
- Ciardi, A.
- Elli, L.
- Caprioli, F.
- Vecchi, M.
- D'Inca, R.
- Zingone, F.
- D'Odorico, A.
- Vincenzo Lenti, M.
- Oreggia, B.
- Reggiani Bonetti, L.
- Astegiano, M.
- Biletta, E.
- Cantoro, L.
- Giannone, A. G.
- Orlandi, A.
- Papi, C.
- Perfetti, V.
- Quaquarini, E.
- Sandri, G.
- Silano, M.
- Usai, P.
- Barresi, V.
- Ciccocioppo, R.
- Luinetti, O.
- Pedrazzoli, P.
- Pietrabissa, A.
- Viglio, A.
- Paulli, M.
- Corazza, G. R.
- Solcia, E.
- Vanoli, A.
- Di Sabatino, A.
Description
Small bowel adenocarcinomas (SBAs) are often associated with poor prognosis and have limited therapeutic options. Programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway blockade is an effective treatment in many microsatellite instability-high (MSI-H) solid tumors. We aimed at investigating PD-L1 and PD-1 expression in non-hereditary, non-ampullary SBAs, associated with celiac disease (CeD), Crohn's disease (CrD), or sporadic, recruited through the Small Bowel Cancer Italian Consortium. We assessed PD-L1 and PD-1 by immunohistochemistry in a series of 121 surgically resected SBAs, including 34 CeD-SBAs, 49 CrD-SBAs, and 38 sporadic SBAs. PD-L1 and PD-1 expression was correlated with several clinico-pathological features, such as the etiology, microsatellite instability status, and tumor-infiltrating lymphocyte (TIL) density. The prevalence of PD-L1 positivity according to combined positive score (CPS) was 26% in the whole cohort of SBAs, with significantly (p = 0.001) higher percentage (35%) in both CeD-SBAs and CrD-SBAs in comparison with sporadic SBAs (5%). CPS ≥ 1 SBAs were significantly (p = 0.013) more frequent in MSI-H cases (41%) than in non-MSI-H ones (18%); however, 15 CPS ≥ 1 microsatellite stable SBAs were also identified. CPS ≥ 1 SBAs showed higher TIL and PD-1+ immune cell density, more frequently medullary histotype, as well as a better outcome in comparison with CPS < 1 cases. This study demonstrates an increased proportion of PD-L1+ cases in both CeD-SBAs and CrD-SBAs in comparison with sporadic SBAs. In addition, the identification of a subset of PD-L1+ microsatellite stable SBAs supports the need to ascertain additional biomarkers of response to immune checkpoint inhibitors along with MSI-H.
Additional details
- URL
- http://hdl.handle.net/11567/1001505
- URN
- urn:oai:iris.unige.it:11567/1001505
- Origin repository
- UNIGE