Using peripheral immune-inflammatory blood markers in tumors treated with immune checkpoint inhibitors: An INVIDIa-2 study sub-analysis
- Creators
- Anpalakhan S.
- Signori A.
- Cortellini A.
- Verzoni E.
- Giusti R.
- Aprile G.
- Ermacora P.
- Catino A.
- Pipitone S.
- Di Napoli M.
- Scotti V.
- Mazzoni F.
- Guglielmini P. F.
- Veccia A.
- Maruzzo M.
- Schinzari G.
- Casadei C.
- Grossi F.
- Rizzo M.
- Montesarchio V.
- Verderame F.
- Mencoboni M.
- Zustovich F.
- Fratino L.
- Accettura C.
- Cinieri S.
- Tondini C. A.
- Camerini A.
- Banzi M. C.
- Soraru M.
- Zucali P. A.
- Vignani F.
- Ricciardi S.
- Russo A.
- Cosenza A.
- Di Maio M.
- De Giorgi U.
- Pignata S.
- Giannarelli D.
- Pinto C.
- Buti S.
- Fornarini G.
- Rebuzzi S. E.
- Rescigno P.
- Addeo A.
- Banna G. L.
- Bersanelli M.
- Others:
- Anpalakhan, S.
- Signori, A.
- Cortellini, A.
- Verzoni, E.
- Giusti, R.
- Aprile, G.
- Ermacora, P.
- Catino, A.
- Pipitone, S.
- Di Napoli, M.
- Scotti, V.
- Mazzoni, F.
- Guglielmini, P. F.
- Veccia, A.
- Maruzzo, M.
- Schinzari, G.
- Casadei, C.
- Grossi, F.
- Rizzo, M.
- Montesarchio, V.
- Verderame, F.
- Mencoboni, M.
- Zustovich, F.
- Fratino, L.
- Accettura, C.
- Cinieri, S.
- Tondini, C. A.
- Camerini, A.
- Banzi, M. C.
- Soraru, M.
- Zucali, P. A.
- Vignani, F.
- Ricciardi, S.
- Russo, A.
- Cosenza, A.
- Di Maio, M.
- De Giorgi, U.
- Pignata, S.
- Giannarelli, D.
- Pinto, C.
- Buti, S.
- Fornarini, G.
- Rebuzzi, S. E.
- Rescigno, P.
- Addeo, A.
- Banna, G. L.
- Bersanelli, M.
Description
The neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammatory index (SII) have been reported as prognosticators in non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), and melanoma. This analysis of the INVIDIa-2 study on influenza vaccination in patients with cancer treated with immune checkpoint inhibitors (ICIs) assessed NLR and SII on overall survival (OS) by literature-reported (LR), receiver operating characteristic curve (ROC)-derived (ROC) cutoffs or as continuous variable (CV). NLR and SII with ROC cutoffs of <3.4 (p < 0.001) and <831 (p < 0.001) were independent factors for OS in multivariate analysis. SII with LR, ROC, or CV significantly predicted OS in NSCLC (p = 0.002, p = 0.003, p = 0.003), RCC (p = 0.034, p = 0.014, p = 0.014), and melanoma (p = 0.038, p = 0.022, p = 0.019). NLR with LR and ROC cutoffs predicted OS in first line (p < 0.001 for both) and second line or beyond (p = 0.006 for both); likewise SII (p < 0.001; p = 0.002 and p < 0.001). NLR and SII are prognosticators in NSCLC, RCC, and melanoma treated with ICIs.
Additional details
- URL
- https://hdl.handle.net/11567/1152555
- URN
- urn:oai:iris.unige.it:11567/1152555
- Origin repository
- UNIGE