Hyperstructures, genome analysis and i-cell
- Creators
- Norris, V.
- Amar, P.
- Ballet, P.
- Bernot, G.
- Bouligand, Y.
- Bourguine, P.
- Delosme, J.-M.
- Demarty, M.
- Fishov, I.
- Fralick, J.
- Giavitto, J.-L.
- Gleyse, B.
- Godin, Christophe
- Incitti, R.
- Lange, C.
- Le Sceller, L.
- Loutellier, C.
- Michel, O.
- Molina, F.
- Monnier, C.
- Moreno, C.
- Orange, N.
- Pollard, H.
- Raine, D.
- Rambourg, A.
- Ramsden, J.
- Ripoll, C.
- Rouviere-Yaniv, J.
- Saier Jnr., M.
- Soler, P.
- Thellier, M.
- Tracqui, Ph.
- Ussery, D.
- Valleton, J.-M.
- Vannier, J.-P.
- Wiggins, P.
- Zemirline, A.
- Képès, F.
- Others:
- Northeast States for Coordinated Air Use Management (NESCAUM) ; Northeast States for Coordinated Air Use Management (NESCAUM)
- Environnement Illimite
- Laboratoire Hippolyte Fizeau (FIZEAU) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)
- Laboratoire de Planétologie et Géodynamique [UMR 6112] (LPG) ; Université d'Angers (UA)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST) ; Université de Nantes (UN)-Université de Nantes (UN)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)
- Laboratoire de Microbiologie du Froid – Signaux et Micro-Environnement (LMDF-SME) ; Université de Rouen Normandie (UNIROUEN) ; Normandie Université (NU)-Normandie Université (NU)
- Régulation de l'expression génétique chez les microorganismes (REGCM) ; Centre National de la Recherche Scientifique (CNRS)
- Service de Parasitologie - Mycologie [CHU Pitié-Salpétrière] ; CHU Pitié-Salpêtrière [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
- Wiggins Observatory ; Wiggins Observatory
Description
New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology.
Abstract
International audience
Additional details
- URL
- https://hal.univ-brest.fr/hal-00997938
- URN
- urn:oai:HAL:hal-00997938v1
- Origin repository
- UNICA