Serum Markers of Hepatocyte Death and Apoptosis Are Non Invasive Biomarkers of Severe Fibrosis in Patients with Alcoholic Liver Disease

Creators: Lavallard, Vanessa Jeannette; Bonnafous, Stéphanie; Patouraux, Stéphanie; Saint-Paul, Marie-Christine; Rousseau, Déborah; Anty, Rodolphe; Le Marchand-Brustel, Yannick; Tran, Albert; Gual, Philippe

Others:: Pôle Digestif ; Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital l'Archet; Centre méditérannéen de médecine moléculaire (C3M) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM); Université Côte d'Azur (UniCA); Centre Hospitalier Universitaire de Nice (CHU Nice); Hôpital Pasteur [Nice] (CHU); Pôle Digestif ; Hôpital Archet 2 [Nice] (CHU); Centre méditerranéen de médecine moléculaire (C3M) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UniCA); Hôpital Archet 2 [Nice] (CHU); Signalisation moléculaire et obésité ; Université Nice Sophia Antipolis (1965 - 2019) (UNS)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM)

Description

Quantification of hepatocyte death is useful to evaluate the progression of alcoholic liver diseases. Our aims were to quantify and correlate the circulating levels of Cytokeratin 18 (CK18) and its caspases-generated fragment to disease severity in heavy alcoholics.

Abstract

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Serum Markers of Hepatocyte Death and Apoptosis Are Non Invasive Biomarkers of Severe Fibrosis in Patients with Alcoholic Liver Disease

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Abstract

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