Published July 4, 2023
| Version v1
Publication
Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa
Description
There is an increasing attention to the emerging health problem represented by the clinical
and functional long-term consequences of SARS-CoV-2 infection, referred to as postacute COVID-19
syndrome. Clinical, radiographic, and autopsy findings have shown that a high rate of fibrosis and
restriction of lung function are present in patients who have recovered from COVID-19. Patients with
active TB, or those who have recovered from it, have fibrotic scarred lungs and, consequently, some
degree of impaired respiratory function. Helminth infections trigger predominantly type 2 immune
responses and the release of regulatory and fibrogenic cytokines, such as TGF-β. Here, we analyze
the possible consequences of the overlapping of pulmonary fibrosis secondary to COVID-19 and
tuberculosis in the setting of sub-Saharan Africa, the region of the world with the highest prevalence
of helminth infection.
Additional details
Identifiers
- URL
- https://idus.us.es/handle//11441/147696
- URN
- urn:oai:idus.us.es:11441/147696
Origin repository
- Origin repository
- USE