Published 2013
| Version v1
Publication
Cancer chemopreventive diterpenes from Salvia corrugata
Description
NMR and NP-HPLC-UV profiling of the exudate of Salvia corrugata revealed that its secondary metabolite
composition was largely dominated by a-hydroxy-b-isopropyl-benzoquinone diterpenoids. Among them,
four diterpenes not described previously were isolated and identified as fruticulin C (3), 7a-methoxy-19-
acetoxy-royleanone (4), 7a,19-diacetoxy-royleanone (5), and 7-dehydroxy-conacytone (7). In addition,
the known diterpenes fruticulin A (1), demethyl-fruticulin A (2) and 7a-O-methyl-conacytone (6) were
also obtained. The isolated compounds were evaluated for their cancer chemopreventive activity by measuring
quinone reductase induction activity and histone deacetylase inhibition. Three compounds (1, 2
and 5) showed promising activity.
Additional details
Identifiers
- URL
- http://hdl.handle.net/11567/649567
- URN
- urn:oai:iris.unige.it:11567/649567
Origin repository
- Origin repository
- UNIGE