Published 2014 | Version v1
Publication Metadata-only

Lapatinib concentration in cerebrospinal fluid in two patients with HER2-positive metastatic breast cancer and brain metastases

Gori S
Lunardi G
Inno A
Foglietta J
Cardinali B
Del Mastro L
Crino L
Others:
Gori, S
Lunardi, G
Inno, A
Foglietta, J
Cardinali, B
Del Mastro, L
Crino, L

Description

Lapatinib is able to penetrate brain metastases from HER2-positive breast cancer. We assessed lapatinib concentration in cerebrospinal fluid (CSF) of two patients with HER2-positive metastatic breast cancer and brain metastases, and we found low levels of the drug in CSF of both patients. Lapatinib concentration in CSF may not be a reliable surrogate of its distribution in brain metastases.

Additional details

Identifiers Origin repository
Created:
April 14, 2023
Modified:
November 29, 2023