Published 2017
| Version v1
Publication
Active HCV Replication but Not HCV or CMV Seropositive Status Is Associated with Incident and Prevalent Type 2 Diabetes in Persons Living with HIV
Creators
- De Luca A.
- Lorenzini P.
- Castagna A.
- Puoti M.
- Gianotti N.
- Castelli F.
- Mastroianni C.
- Maggiolo F.
- Antinori A.
- Guaraldi G.
- Lichtner M.
- D'Arminio Monforte A.
- Andreoni M.
- Angarano G.
- Cauda R.
- Di Perri G.
- Galli M.
- Iardino R.
- Ippolito G.
- Lazzarin A.
- Perno C. F.
- Von Schloesser F.
- Viale P.
- Ceccherini-Silberstein F.
- Cozzi-Lepri A.
- Girardi E.
- Lo Caputo S.
- Mussini C.
- Ammassari A.
- Balotta C.
- Bandera A.
- Bonfanti P.
- Bonora S.
- Borderi M.
- Calcagno A.
- Calza L.
- Capobianchi M. R.
- Cingolani A.
- Cinque P.
- Di Biagio A.
- Gori A.
- Lapadula G.
- Madeddu G.
- Marchetti G.
- Marcotullio S.
- Monno L.
- Nozza S.
- Quiros Roldan E.
- Rossotti R.
- Rusconi S.
- Santoro M. M.
- Saracino A.
- Zaccarelli M.
- Fanti I.
- Galli L.
- Rodano A.
- Shanyinde M.
- Tavelli A.
- Carletti F.
- Carrara S.
- Di Caro A.
- Graziano S.
- Petrone F.
- Prota G.
- Quartu S.
- Truffa S.
- Giacometti A.
- Costantini A.
- Valeriani C.
- Santoro C.
- Suardi C.
- Donati V.
- Verucchi G.
- Minardi C.
- Quirino T.
- Abeli C.
- Manconi P. E.
- Piano P.
- Cacopardo B.
- Celesia B.
- Vecchiet J.
- Falasca K.
- Sighinolfi L.
- Segala D.
- Mazzotta F.
- Vichi F.
- Cassola G.
- Viscoli C.
- Alessandrini A.
- Bobbio N.
- Mazzarello G.
- Belvisi V.
- Caramma I.
- Chiodera A.
- Castelli A. P.
- Rizzardini G.
- Ridolfo A. L.
- Piolini R.
- Salpietro S.
- Carenzi L.
- Moioli M. C.
- Tincati C.
- Puzzolante C.
- Abrescia N.
- Chirianni A.
- Borgia G.
- Di Martino F.
- Maddaloni L.
- Gentile I.
- Orlando R.
- Baldelli F.
- Francisci D.
- Parruti G.
- Ursin T.
- Magnani G.
- Ursitti M. A.
- Vullo V.
- Cristaudo A.
- Baldin G.
- Cicalini S.
- Gallo L.
- Nicastri E.
- Acinapura R.
- Capozzi M.
- Libertone R.
- Savinelli S.
- Latini A.
- Iaiani G.
- Fontanelli Sulekova L.
- Cecchetto M.
- Viviani F.
- Mura M. S.
- Rossetti B.
- Caramello P.
- Orofino G. C.
- Sciandra M.
- Bassetti M.
- Londero A.
- Pellizzer G.
- Manfrin V.
Contributors
Others:
- De Luca, A.
- Lorenzini, P.
- Castagna, A.
- Puoti, M.
- Gianotti, N.
- Castelli, F.
- Mastroianni, C.
- Maggiolo, F.
- Antinori, A.
- Guaraldi, G.
- Lichtner, M.
- D'Arminio Monforte, A.
- Andreoni, M.
- Angarano, G.
- Cauda, R.
- Di Perri, G.
- Galli, M.
- Iardino, R.
- Ippolito, G.
- Lazzarin, A.
- Perno, C. F.
- Von Schloesser, F.
- Viale, P.
- Ceccherini-Silberstein, F.
- Cozzi-Lepri, A.
- Girardi, E.
- Lo Caputo, S.
- Mussini, C.
- Ammassari, A.
- Balotta, C.
- Bandera, A.
- Bonfanti, P.
- Bonora, S.
- Borderi, M.
- Calcagno, A.
- Calza, L.
- Capobianchi, M. R.
- Cingolani, A.
- Cinque, P.
- Di Biagio, A.
- Gori, A.
- Lapadula, G.
- Madeddu, G.
- Marchetti, G.
- Marcotullio, S.
- Monno, L.
- Nozza, S.
- Quiros Roldan, E.
- Rossotti, R.
- Rusconi, S.
- Santoro, M. M.
- Saracino, A.
- Zaccarelli, M.
- Fanti, I.
- Galli, L.
- Rodano, A.
- Shanyinde, M.
- Tavelli, A.
- Carletti, F.
- Carrara, S.
- Di Caro, A.
- Graziano, S.
- Petrone, F.
- Prota, G.
- Quartu, S.
- Truffa, S.
- Giacometti, A.
- Costantini, A.
- Valeriani, C.
- Santoro, C.
- Suardi, C.
- Donati, V.
- Verucchi, G.
- Minardi, C.
- Quirino, T.
- Abeli, C.
- Manconi, P. E.
- Piano, P.
- Cacopardo, B.
- Celesia, B.
- Vecchiet, J.
- Falasca, K.
- Sighinolfi, L.
- Segala, D.
- Mazzotta, F.
- Vichi, F.
- Cassola, G.
- Viscoli, C.
- Alessandrini, A.
- Bobbio, N.
- Mazzarello, G.
- Belvisi, V.
- Caramma, I.
- Chiodera, A.
- Castelli, A. P.
- Rizzardini, G.
- Ridolfo, A. L.
- Piolini, R.
- Salpietro, S.
- Carenzi, L.
- Moioli, M. C.
- Tincati, C.
- Puzzolante, C.
- Abrescia, N.
- Chirianni, A.
- Borgia, G.
- Di Martino, F.
- Maddaloni, L.
- Gentile, I.
- Orlando, R.
- Baldelli, F.
- Francisci, D.
- Parruti, G.
- Ursin, T.
- Magnani, G.
- Ursitti, M. A.
- Vullo, V.
- Cristaudo, A.
- Baldin, G.
- Cicalini, S.
- Gallo, L.
- Nicastri, E.
- Acinapura, R.
- Capozzi, M.
- Libertone, R.
- Savinelli, S.
- Latini, A.
- Iaiani, G.
- Fontanelli Sulekova, L.
- Cecchetto, M.
- Viviani, F.
- Mura, M. S.
- Rossetti, B.
- Caramello, P.
- Orofino, G. C.
- Sciandra, M.
- Bassetti, M.
- Londero, A.
- Pellizzer, G.
- Manfrin, V.
Description
Objective: To analyze the association between chronic hepatitis C virus (HCV) and cytomegalovirus (CMV) infections with type 2 diabetes in HIV-infected patients. Methods: HIV-1-infected patients enrolled in ICONA, a prospective cohort study involving 42 tertiary care centers in Italy, were selected with the following characteristics: for the diabetes incidence analysis, all patients with available CMV IgG results (first available test = baseline) and without type 2 diabetes were followed until onset of type 2 diabetes, last available clinical follow-up, death or September 30, 2014, whichever occurred first; for the prevalence analysis, all ICONA patients were analyzed at their last follow-up visit. Main outcome measures were the new onset of type 2 diabetes (incidence analysis) and the prevalence of type 2 diabetes at last follow-up. Results: During 38,062 person-years of follow-up (PYFU) in 6505 individuals, we observed 140 cases of incident type 2 diabetes (Incidence rate 3.7, 95% CI: 3.1 to 4.3, per 1000 PYFU). In a multivariable Poisson regression model, HCV-antibody (Ab)+/HCV RNA+ patients [adjusted relative rate versus HCV-Ab negative 1.73 (95% CI: 1.08 to 2.78)] but not HCV Ab+RNA- or CMV IgG+ patients, had a higher risk of diabetes. Among 12,001 patients, 306 (2.5%) prevalent cases of type 2 diabetes were detected. HCV Ab+RNA+ status was independently associated with prevalent diabetes (adjusted Odds Ratio vs HCV Ab- 2.49; 95% CI: 1.08 to 5.74), whereas HCV-Ab+/HCV RNA- and CMV IgG+ status were not. Conclusion: In HIV-infected individuals, active HCV replication but not prior HCV exposure or latent CMV infection is associated with incident and prevalent type 2 diabetes.
Additional details
Identifiers
- URL
- http://hdl.handle.net/11567/893292
- URN
- urn:oai:iris.unige.it:11567/893292
Origin repository
- Origin repository
- UNIGE