Safe use of proton-pump inhibitors

Proton-pump inhibitors (PPIs) are one of the most widely used drug classes worldwide. Their discovery goes back to the 1980s, when the significance of H+/K+-ATPase in gastric acid production was established. The market launch of PPIs, which inhibit this enzyme by direct, irreversible binding, paved the way to a new age in the management of gastrointestinal conditions related to stomach acid secretion (1).