1,2,3-Triazoles from carbonyl azides and alkynes: filling the gap

Description

Electron deficient azides are challenging substrates in CuAAC reactions. Particularly, when N-carbonyl azides are applied the formation of N-carbonyl triazoles has not yet been observed. We report herein the first example of this class of reaction, with a copper-based system that efficiently enables the synthesis of N-carbamoyl 1,2,3-triazoles by [3+2] cycloaddition of N-carbamoyl azides and alkynes

Abstract

Ministerio de Economía y Competitividad CTQ2011-28942-CO2-01, CTQ2011-27033

Abstract

Junta de Andalucía P07-FQM-02745, P10-FQM-06292

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