HLA-DRB∗1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis

Creators: Yaldizli, Özgür; Sethi, Varun; PARDINI, MATTEO; Tur, Carmen; Mok, Kin Y.; Muhlert, Nils; Liu, Zheng; Samson, Rebecca S.; Wheeler Kingshott, Claudia A. M.; Yousry, Tarek A.; Houlden, Henry; Hardy, John; Miller, David H.; Chard, Declan T.

Others:: Yaldizli, Özgür; Sethi, Varun; Pardini, Matteo; Tur, Carmen; Mok, Kin Y.; Muhlert, Nil; Liu, Zheng; Samson, Rebecca S.; Wheeler Kingshott, Claudia A. M.; Yousry, Tarek A.; Houlden, Henry; Hardy, John; Miller, David H.; Chard, Declan T.

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Background The HLA-DRB∗1501 haplotype influences the risk of developing multiple sclerosis (MS), but it is not known how it affects grey matter pathology. Aim To assess HLA-DRB∗1501 effects on magnetic resonance imaging (MRI) cortical grey matter pathology. Methods Whole and lesional cortical grey matter volumes, lesional and normal-appearing grey matter magnetization transfer ratio were measured in 85 people with MS and 36 healthy control subjects. HLA-DRB∗1501 haplotype was determined by genotyping (rs3135388). Results No significant differences were observed in MRI measures between the HLA-DRB∗1501 subgroups. Conclusions The HLA-DRB∗1501 haplotype is not strongly associated with MRI-visible grey matter pathology.

HLA-DRB∗1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis

Description

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