Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols.

Creators: Bello C; Dal Bello G; CEA, MICHELE; Nahimana A; Aubry D; GARUTI, ANNA; MOTTA, GIULIA; MORAN, EVA; FRUSCIONE, FLORIANA; Pronzato P; Grossi F; PATRONE, FRANCO; BALLESTRERO, ALBERTO; Dupuis M; Sordat B; Zimmermann K; Loretan J; Wartmann M; Duchosal MA; NENCIONI, ALESSIO; Vogel P.

Others:: Bello, C; Dal Bello, G; Cea, Michele; Nahimana, A; Aubry, D; Garuti, Anna; Motta, Giulia; Moran, Eva; Fruscione, Floriana; Pronzato, P; Grossi, F; Patrone, Franco; Ballestrero, Alberto; Dupuis, M; Sordat, B; Zimmermann, K; Loretan, J; Wartmann, M; Duchosal, Ma; Nencioni, Alessio; Vogel, P.

Description

New derivatives of 1,4-dideoxy-1,4-imino-D-ribitol have been prepared and evaluated for their cytotoxicity on solid and haematological malignancies. 1,4-Dideoxy-5-O-[(9Z)-octadec-9-en-1-yl]-1,4-imino-Dribitol (13, IC50 similar to 2 mu M) and its C-18-analogues (IC50 < 10 mu M) are cytotoxic toward SKBR3 (breast cancer) cells. 13 also inhibits (IC50 similar to 8 mu M) growth of JURKAT cells. (C) 2011 Published by Elsevier Ltd.

Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols.

Description

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