1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors

Creators: Haarr, Marianne B.; López López, Óscar; Pejov, Ljupcho; Fernández-Bolaños Guzmán, José María; Lindbäck, Emil; Sydnes, Magne O.

Other:: Universidad de Sevilla. Departamento de Química orgánica

Description

The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase in the submicromolar concentration ranges (Ki values ranging from 0.23 to 1.4 μM).

Abstract

España, Dirección General de Investigación (CTQ2016-78703-P)

Abstract

Junta de Andalucía (FQM134)

1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors

Description

Abstract

Abstract

Additional details