Unveiling the Dispersion Kernel in DSC-MRI by Means of Dispersion-Compliant Bases and Control Point Interpolation Techniques

In DSC-MRI the presence of dispersion affects the estimation, via deconvolution, of the residue function that characterizes the perfusion in each voxel. Dispersion is descibed by a Vascular Transport Function (VTF) which knolewdge is essential to recover a dispersion-free residue function. State-of-the-art techniques aim at characterizing the VTF but assume a specific shape for it, which in reality is unknown. We propose to estimate the residue function without assumptions by means of Dispersion-Compliant Bases (DCB). We use these results to find which VTF model better describes the in vivo data for each tissue type by means of control point interpolation approaches.