The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging

Creators: Wohlwend, Martin; Laurila, Pirkka-Pekka; Williams, Kristine; Romani, Mario; Lima, Tanes; Pattawaran, Pattamaprapanont; Benegiamo, Giorgia; Salonen, Minna; Schneider, Bernard; Lahti, Jari; Eriksson, Johan; Barrès, Romain; Wisløff, Ulrik; Moreira, José; Auwerx, Johan

Others:: Institut Dolomieu (géologie) ; Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS); University of Turku; Helsingin yliopisto = Helsingfors universitet = University of Helsinki; Folkhälsan Research Center ; Faculty of Medecine [Helsinki] ; Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki; Agency for science, technology and research [Singapore] (A*STAR); National University of Singapore (NUS); Institut de pharmacologie moléculaire et cellulaire (IPMC) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA); Valory AG; Ecole Polytechnique Fédérale de Lausanne (EPFL)

Description

Exercise activates the lncRNA Cytor , which reestablishes fast-twitch muscle fibers in aged skeletal muscle, improving morphology and function.

International audience