Extra-cellular matrix rigidity may dictate the fate of injury outcome
- Others:
- Modelling and Analysis for Medical and Biological Applications (MAMBA) ; Inria de Paris ; Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Jacques-Louis Lions (LJLL (UMR_7598)) ; Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
- STROMALab ; Université Toulouse III - Paul Sabatier (UT3) ; Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS)
- Mathématiques pour les Neurosciences (MATHNEURO) ; Inria Sophia Antipolis - Méditerranée (CRISAM) ; Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)
- Department of Mathematics [Imperial College London] ; Imperial College London
Description
After injury, while regeneration can be observed in hydra, planaria and some vertebrates,regeneration is rare in mammals and particularly in humans. In this paper, we investigatethe mechanisms by which biological tissues recover after injury. We explore this question onadipose tissue, using the mathematical framework recently developed in Peurichard et al.,J. Theoret. Biol. 429 (2017), pp. 61-81. Our assumption is that simple mechanical cuesbetween the Extra-Cellular Matrix (ECM) and differentiated cells can explain adipose tissuemorphogenesis and that regeneration requires after injury the same mechanisms. We validatethis hypothesis by means of a two-dimensional Individual Based Model (IBM) of interactingadipocytes and ECM fiber elements. The model successfully generates regeneration or scarformation as functions of few key parameters, and seems to indicate that the fate of injuryoutcome could be mainly due to ECM rigidity.
Abstract
International audience
Additional details
- URL
- https://hal.archives-ouvertes.fr/hal-02345773
- URN
- urn:oai:HAL:hal-02345773v1
- Origin repository
- UNICA