Association of PEEP and Lung Recruitment Selection Strategies with Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Network Meta-Analysis

Description

Rationale: The most beneficial positive end-expiratory pressure (PEEP) selection strategy in patients with acute respiratory distress syndrome (ARDS) is unknown and current practice is variable. Objectives: To compare the relative effects of different PEEP selection strategies on mortality in adults with moderate to severe ARDS. Methods: We conducted a network meta-analysis using a Bayesian framework. Certainty of evidence was evaluated using GRADE methodology. Results: We included 18 randomized trials (4646 participants). In comparison to a lower PEEP strategy, the posterior probability of mortality benefit from a higher PEEP without lung recruitment maneuver (LRM) strategy was 99% (RR 0.77, 95% Crl 0.60-0.96, high certainty), the posterior probability of benefit of the Pes-guided strategy was 87% (RR 0.77, 95% CrI 0.48-1.22, moderate certainty), the posterior probability of benefit of a higher PEEP with brief LRM strategy was 96% (RR 0.83, 95% CrI 0.67-1.02, moderate certainty), and the posterior probability of increased mortality from a higher PEEP with prolonged LRM strategy was 77% (RR 1.06, 95% Crl 0.89-1.22, low certainty). In comparison to a higher PEEP without LRM strategy, the posterior probability of increased mortality from a higher PEEP with prolonged LRM strategy was 99% (RR 1.37, 95% CrI 1.04-1.81, moderate certainty). Conclusions and relevance: In patients with moderate to severe ARDS, higher PEEP without LRM is associated with a lower risk of death as compared to lower PEEP. A higher PEEP with prolonged LRM strategy is associated with increased risk of death when compared to higher PEEP without LRM.

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