Cardiovascular Polycystins: Insights From Autosomal Dominant Polycystic Kidney Disease and Transgenic Animal Models

Description

Mutations in the PKD1 and PKD2 polycystin genes are responsiblefor autosomal dominant polycystic kidney disease (ADPKD), one ofthe most prevalent genetic kidney disorders. ADPKD is a multisystemdisease characterized by the formation of numerous fluid-filledcysts in the kidneys, the pancreas, and the liver. Moreover, majorcardiovascular manifestations are common complications in ADPKD.Intracranial aneurysms and arterial hypertension are among theleading causes of mortality in this disease. In the present review, wesummarize our current understanding of the role of polycystins in thedevelopment, maintenance, and function of the cardiovascular system.

Abstract

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