Published October 17, 2022
| Version v1
Publication
Editorial: Involvements of TRP channels, oxidative stress and apoptosis in neurodegenerative diseases
Contributors
Description
The oxygen free radicals generated during metabolism can cause cumulative oxidative damage to
nucleic acids, lipids, and protein, resulting in structural degeneration, apoptosis, functional decline,
and age-related degenerative diseases involving the cardiovascular, endocrine, neurologic, immune,
respiratory, gastrointestinal, and reproductive systems. The transient receptor potential (TRP)
protein superfamily is composed of several cation-permeable channels that are widely distributed
in mammalian cells. TRP channels can be divided into six subfamilies that are dependent on
their sequence identity. These channels play a crucial role in the regulation of oxidative stress and
should be considered as likely targets for the treatment of age-related neurodegenerative diseases
associated with chronic oxidative stress, decreases in metabolic regulation, and cell viability.
Additional details
Identifiers
- URL
- https://idus.us.es/handle//11441/137969
- URN
- urn:oai:idus.us.es:11441/137969