Published August 30, 2024 | Version v1
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Pd(II)-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic N-Carbamoyl Hydrazones

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Description

Catalysts generated by combinations of Pd(TFA)2 and pyridine-hydrazone ligands have been applied to 1,2 addition of arylboronic acids to aliphatic N-carbamoyl (Cbz) hydrazones, affording protected α- aryl monoalkylhydrazines with high enantioselectivities (37-99% ee). Subsequent removal of the benzyloxy carbonyl protecting group provides a direct entry to free monosubstituted hydrazines, key building blocks for the synthesis of appealing 1,2-diaza-heterocycles, aminoacid derived hydrazides and other pharmacophores thereof.

Abstract

Ministerio de Economía y Competitividad CTQ2016-76908-C2-1-PCTQ2016-76908-C2-2-P

Abstract

Junta de Andalucía P18-FR-3531, P18-FR-644

Additional details

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URL
https://idus.us.es/handle//11441/162140
URN
urn:oai:idus.us.es:11441/162140

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Origin repository
USE