Published 2011
| Version v1
Publication
Nucleophilic substitutions in the isoindole series as a valuable tool to synthesize derivatives with antitumor activity
Description
A novel synthetic approach to the synthesis of 3-substituted isoindoles through nucleophilic substitution of 3-halo derivatives by charged carbon, and neutral nitrogen, oxygen, and sulfur nucleophiles, assisted by a 1-acyl group, is reported. Aryl-thio-isoindoles, obtained through a direct nucleophilic substitution with sulfur nucleophiles, showed cytotoxic activity, with GI50 values from micromolar to sub-micromolar concentrations, against the total number of cell lines investigated.
Additional details
Identifiers
- URL
- http://hdl.handle.net/11567/1024290
- URN
- urn:oai:iris.unige.it:11567/1024290
Origin repository
- Origin repository
- UNIGE