SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease

Creators: Thomas, Sandhya S; Wu, Jiao; Davogustto, Giovanni; Holliday, Michael W; Eckel-Mahan, Kristin; Verzola, Daniela; Garibotto, Giacomo; Hu, Zhaoyong; Mitch, William E; Taegtmeyer, Heinrich

Others:: Thomas, Sandhya S; Wu, Jiao; Davogustto, Giovanni; Holliday, Michael W; Eckel-Mahan, Kristin; Verzola, Daniela; Garibotto, Giacomo; Hu, Zhaoyong; Mitch, William E; Taegtmeyer, Heinrich

Description

Chronic kidney disease (CKD) is characterized by increased myocardial mass despite near-normal blood pressure, suggesting the presence of a separate trigger. A potential driver is SIRPα (signal regulatory protein alpha)-a mediator impairing insulin signaling. The objective of this study is to assess the role of circulating SIRPα in CKD-induced adverse cardiac remodeling.

SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease

Description

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