Published 2023 | Version v1
Publication Metadata-only

In vivo evolution to echinocandin resistance and increasing clonal heterogeneity in Candida auris during a difficult-to-control hospital outbreak, Italy, 2019 to 2022

Codda G
Willison E
Magnasco L
Morici P
Giacobbe DR
Mencacci A
Marini D
Mikulska M
Bassetti M
Marchese A
Di Pilato V
Others:
Codda, G
Willison, E
Magnasco, L
Morici, P
Giacobbe, Dr
Mencacci, A
Marini, D
Mikulska, M
Bassetti, M
Marchese, A
Di Pilato, V

Description

A difficult-to-control outbreak of Candida auris is ongoing in a large tertiary care hospital in Liguria, Italy, where it first emerged in 2019. In a retrospective analysis, 503 cases of C. auris carriage or infection were observed between July 2019 and December 2022. Genomic surveillance identified putative cases that no longer occurred as part of one defined outbreak and the emergence of echinocandin (pandrug) resistance following independent selection of FKS1S639F and FKS1F635Y mutants upon prolonged exposure to caspofungin and/or anidulafungin.

Additional details

Identifiers Origin repository
Created:
January 31, 2024
Modified:
January 31, 2024