Published July 9, 2007
| Version v1
Journal article
A tarantula peptide against pain via ASIC1a channels and opioid mechanisms.
Contributors
Others:
- Institut de pharmacologie moléculaire et cellulaire (IPMC) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS)
- Pharmacologie fondamentale et clinique de la douleur ; Neuro-Dol (Neuro-Dol) ; Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Department of Molecular Psychiatry ; Rheinische Friedrich-Wilhelms-Universität Bonn
Description
Psalmotoxin 1, a peptide extracted from the South American tarantula Psalmopoeus cambridgei, has very potent analgesic properties against thermal, mechanical, chemical, inflammatory and neuropathic pain in rodents. It exerts its action by blocking acid-sensing ion channel 1a, and this blockade results in an activation of the endogenous enkephalin pathway. The analgesic properties of the peptide are suppressed by antagonists of the mu and delta-opioid receptors and are lost in Penk1(-/-) mice.
Abstract
International audienceAdditional details
Identifiers
- URL
- https://uca.hal.science/hal-04887722
- URN
- urn:oai:HAL:hal-04887722v1
Origin repository
- Origin repository
- UNICA