Published 2019 | Version v1
Publication Metadata-only

Frontal Variant of Alzheimer's Disease: A Report of a Novel PSEN1 Mutation

Monacelli F.
Martella L.
Parodi M. N.
Odetti P.
Fanelli F.
Tabaton M.
Others:
Monacelli, F.
Martella, L.
Parodi, M. N.
Odetti, P.
Fanelli, F.
Tabaton, M.

Description

Alzheimer's disease may mimic frontotemporal dementia. We describe a case of presenile dementia who presented with peudo-psychotic symptoms carrying a PSEN1 mutation (P355S), which was not known to be pathogenic. PET-FDG showed bilateral frontotemporal hypometabolism, but at MRI, multiple microbleeds were detected, suggestive of amyloid angiopathy.

Additional details

Identifiers Origin repository
Created:
April 14, 2023
Modified:
November 28, 2023