ECIL guidelines for preventing Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients
- Creators
- Maertens, Johan
- Cesaro, Simone
- Maschmeyer, Georg
- Einsele, Hermann
- Donnelly, J. Peter
- Alanio, Alexandre
- Hauser, Philippe M.
- Lagrou, Katrien
- Melchers, Willem J. G.
- Helweg-Larsen, Jannik
- Matos, Olga
- Bretagne, Stã©phane
- Cordonnier, Catherine
- Agrawal, Samir
- Kibbler, Christopher
- PAGLIUCA, SIMONE ANTONIO
- Ward, Katherine
- Akova, Murat
- Herbrecht, Raoul
- Mallet, Vincent
- Ribaud, Patricia
- Aljurf, Mahmoud
- Averbuch, Dina
- Engelhard, Dan
- Berg, Thomas
- Cornely, Oliver
- Penack, Olaf
- van Boemmel, Florian
- von Lilienfeld-Toal, Marie
- Blennow, Ola
- Ljungman, Per
- Bruggemann, Roger
- Donnelly, Peter
- Kullberg, Bart-Jan
- Melchers, Willem
- Calandra, Thierry
- Hirsch, Hans
- Marchetti, Oscar
- Orasch, Christina
- Tissot, Frederic
- Castagnola, Elio
- Girmenia, Corrado
- Mikulska, Malgorzata
- Pagano, Livio
- Viscoli, Claudio
- De La Camara, Rafael
- Duarte, Rafael
- Munoz, Patricia
- Drgona, Lubos
- Hargreaves, Ruth
- Hubacek, Petr
- Kouba, Michal
- Racil, Zdenek
- Klyasova, Galina
- Pettrikos, George
- Roilides, Emmanuel
- Skiada, Anna
- Rizzi-Puechal, Valã©rie
- Sinko, Janos
- Slavin, Monica
- Styczynski, Jan
- Tweddle, Lorraine
- Wood, Craig
- Others:
- Maertens, Johan
- Cesaro, Simone
- Maschmeyer, Georg
- Einsele, Hermann
- Donnelly, J. Peter
- Alanio, Alexandre
- Hauser, Philippe M.
- Lagrou, Katrien
- Melchers, Willem J. G.
- Helweg-Larsen, Jannik
- Matos, Olga
- Bretagne, Stã©phane
- Cordonnier, Catherine
- Agrawal, Samir
- Kibbler, Christopher
- Pagliuca, SIMONE ANTONIO
- Ward, Katherine
- Akova, Murat
- Herbrecht, Raoul
- Mallet, Vincent
- Ribaud, Patricia
- Aljurf, Mahmoud
- Averbuch, Dina
- Engelhard, Dan
- Berg, Thoma
- Cornely, Oliver
- Penack, Olaf
- van Boemmel, Florian
- von Lilienfeld-Toal, Marie
- Blennow, Ola
- Ljungman, Per
- Bruggemann, Roger
- Donnelly, Peter
- Kullberg, Bart-Jan
- Melchers, Willem
- Calandra, Thierry
- Hirsch, Han
- Marchetti, Oscar
- Orasch, Christina
- Tissot, Frederic
- Castagnola, Elio
- Girmenia, Corrado
- Mikulska, Malgorzata
- Pagano, Livio
- Viscoli, Claudio
- De La Camara, Rafael
- Duarte, Rafael
- Munoz, Patricia
- Drgona, Lubo
- Hargreaves, Ruth
- Hubacek, Petr
- Kouba, Michal
- Racil, Zdenek
- Klyasova, Galina
- Pettrikos, George
- Roilides, Emmanuel
- Skiada, Anna
- Rizzi-Puechal, Valã©rie
- Sinko, Jano
- Slavin, Monica
- Styczynski, Jan
- Tweddle, Lorraine
- Wood, Craig
Description
The 5th European Conference on Infections in Leukaemia (ECIL-5) meeting aimed to establish evidence-based recommendations for the prophylaxis of Pneumocystis jirovecii pneumonia (PCP) in non-HIV-infected patients with an underlying haematological condition, including allogeneic HSCT recipients. Recommendations were based on the grading system of the IDSA. Trimethoprim/sulfamethoxazole given 2-3 times weekly is the drug of choice for the primary prophylaxis of PCP in adults (A-II) and children (A-I) and should be given during the entire period at risk. Recent data indicate that children may benefit equally from a once-weekly regimen (B-II). All other drugs, including pentamidine, atovaquone and dapsone, are considered second-line alternatives when trimethoprim/ sulfamethoxazole is poorly tolerated or contraindicated. The main indications of PCP prophylaxis are ALL, allogeneic HSCT, treatment with alemtuzumab, fludarabine/cyclophosphamide/rituximab combinations, >4 weeks of treatmentwith corticosteroids andwell-defined primary immune deficiencies in children. Additional indications are proposed depending on the treatment regimen.
Additional details
- URL
- https://hdl.handle.net/11567/875086
- URN
- urn:oai:iris.unige.it:11567/875086
- Origin repository
- UNIGE