Published 2017 | Version v1
Publication Metadata-only

Activating Killer Immunoglobulin Receptors and HLA-C: A successful combination providing HIV-1 control

Malnati M. S.
Ugolotti E.
Monti M. C.
De Battista D.
Vanni I.
Bordo D.
Sironi F.
Larghero P.
Di Marco E.
Biswas P.
Poli G.
Vicenzi E.
Riva A.
Tarkowski M.
Tambussi G.
Nozza S.
Tripodi G.
Marras F.
De Maria A.
Pistorio A.
Biassoni R.
Others:
Malnati, M. S.
Ugolotti, E.
Monti, M. C.
De Battista, D.
Vanni, I.
Bordo, D.
Sironi, F.
Larghero, P.
Di Marco, E.
Biswas, P.
Poli, G.
Vicenzi, E.
Riva, A.
Tarkowski, M.
Tambussi, G.
Nozza, S.
Tripodi, G.
Marras, F.
De Maria, A.
Pistorio, A.
Biassoni, R.

Description

Several studies demonstrated a relevant role of polymorphisms located within the HLA-B and -C loci and the Killer Immunoglobulin Receptors (KIRs) 3DL1 and 3DS1 in controlling HIV-1 replication. KIRs are regulatory receptors expressed at the surface of NK and CD8+ T-cells that specifically bind HLA-A and -B alleles belonging to the Bw4 supratype and all the -C alleles expressing the C1 or C2 supratype. We here disclose a novel signature associated with the Elite Controller but not with the long-term nonprogressor status concerning 2DS activating KIRs and HLA-C2 alleles insensitive to miRNA148a regulation. Overall, our findings support a crucial role of NK cells in the control of HIV-1 viremia.

Additional details

Identifiers Origin repository
Created:
April 14, 2023
Modified:
November 30, 2023