Synthesis, Structure, and Cytotoxicity of Urukthapelstatin A Polyazole Cyclopeptide Analogs

Description

Analogs of the natural product urukthapelstatin A that belongs to the rare family of polyazole cyclopeptides were synthesized and their cytotoxic activities were determined to gather data toward structure-activity relationships. Crucial steps within the convergent syntheses were a macrothiolacton-ization and a subsequent aza-Wittig reaction to install the het-erocyclic backbone. The synthesis design was proven to be generally suitable for the formation of these azole containing cyclo

Abstract

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