Published 2022
| Version v1
Publication
Endothelial SIRT6 deficiency promotes arterial thrombosis in mice
Creators
- Gaul, Daniel S
- Calatayud, Natacha
- Pahla, Jürgen
- Bonetti, Nicole R
- Wang, Yu-Jen
- Weber, Julien
- Ambrosini, Samuele
- Liberale, Luca
- Costantino, Sarah
- Mohammed, Shafeeq A
- Kraler, Simon
- Van Tits, Lambertus J
- Pasterk, Lisa
- Vdovenko, Daria
- Akhmedov, Alexander
- Ruschitzka, Frank
- Paneni, Francesco
- Lüscher, Thomas F
- Camici, Giovanni G
- Matter, Christian M
Contributors
Others:
- Gaul, Daniel S
- Calatayud, Natacha
- Pahla, Jürgen
- Bonetti, Nicole R
- Wang, Yu-Jen
- Weber, Julien
- Ambrosini, Samuele
- Liberale, Luca
- Costantino, Sarah
- Mohammed, Shafeeq A
- Kraler, Simon
- Van Tits, Lambertus J
- Pasterk, Lisa
- Vdovenko, Daria
- Akhmedov, Alexander
- Ruschitzka, Frank
- Paneni, Francesco
- Lüscher, Thomas F
- Camici, Giovanni G
- Matter, Christian M
Description
Arterial thrombosis may be initiated by endothelial inflammation or denudation, activation of blood-borne elements or the coagulation system. Tissue factor (TF), a central trigger of the coagulation cascade, is regulated by the pro-inflammatory NF-κB-dependent pathways. Sirtuin 6 (SIRT6) is a nuclear member of the sirtuin family of NAD+-dependent deacetylases and is known to inhibit NF-κB signaling. Its constitutive deletion in mice shows early lethality with hypoglycemia and accelerated aging. Of note, the role of SIRT6 in arterial thrombosis remains unknown. Thus, we hypothesized that endothelial SIRT6 protects from arterial thrombosis by modulating inhibition of NF-κB-associated pathways.
Additional details
Identifiers
- URL
- https://hdl.handle.net/11567/1101235
- URN
- urn:oai:iris.unige.it:11567/1101235