Published August 28, 2017
| Version v1
Publication
Real-Time Electrical Bioimpedance Characterization of Neointimal Tissue for Stent Applications
Description
To follow up the restenosis in arteries stented during an angioplasty is an important current
clinical problem. A new approach to monitor the growth of neointimal tissue inside the stent is
proposed on the basis of electrical impedance spectroscopy (EIS) sensors and the oscillation-based test
(OBT) circuit technique. A mathematical model was developed to analytically describe the histological
composition of the neointima, employing its conductivity and permittivity data. The bioimpedance
model was validated against a finite element analysis (FEA) using COMSOL Multiphysics software.
A satisfactory correlation between the analytical model and FEA simulation was achieved in most
cases, detecting some deviations introduced by the thin "double layer" that separates the neointima
and the blood. It is hereby shown how to apply conformal transformations to obtain bioimpedance
electrical models for stack-layered tissues over coplanar electrodes. Particularly, this can be applied
to characterize the neointima in real-time. This technique is either suitable as a main mechanism
for restenosis follow-up or it can be combined with proposed intelligent stents for blood pressure
measurements to auto-calibrate the sensibility loss caused by the adherence of the tissue on the
micro-electro-mechanical sensors (MEMSs).
Abstract
España Ministerio de Economía, Industria y Competitividad TEC2013-46242-C3-1-PAbstract
España Ministerio de Economía, Industria y Competitividad TEC2013-46242-C3Additional details
Identifiers
- URL
- https://idus.us.es/handle/11441/64036
- URN
- urn:oai:idus.us.es:11441/64036