Published 2022
| Version v1
Publication
Evaluating long-term outcomes of three approaches to retroperitoneal staging in endometrial cancer
Creators
- Bogani G.
- Di Donato V.
- Papadia A.
- Buda A.
- Casarin J.
- Multinu F.
- Plotti F.
- Cuccu I.
- D'Auge T. G.
- Gasparri M. L.
- Pinelli C.
- Perrone A. M.
- Barra F.
- Sorbi F.
- Cromi A.
- Di Martino G.
- Palaia I.
- Perniola G.
- Ferrero S.
- De Iaco P.
- Perrone C.
- Angioli R.
- Luvero D.
- Muzii L.
- Ghezzi F.
- Landoni F.
- Mueller M. D.
- Benedetti Panici P.
- Raspagliesi F.
Contributors
Others:
- Bogani, G.
- Di Donato, V.
- Papadia, A.
- Buda, A.
- Casarin, J.
- Multinu, F.
- Plotti, F.
- Cuccu, I.
- D'Auge, T. G.
- Gasparri, M. L.
- Pinelli, C.
- Perrone, A. M.
- Barra, F.
- Sorbi, F.
- Cromi, A.
- Di Martino, G.
- Palaia, I.
- Perniola, G.
- Ferrero, S.
- De Iaco, P.
- Perrone, C.
- Angioli, R.
- Luvero, D.
- Muzii, L.
- Ghezzi, F.
- Landoni, F.
- Mueller, M. D.
- Benedetti Panici, P.
- Raspagliesi, F.
Description
Objective: Sentinel lymph node mapping (SNM) has gained popularity in managing apparent early-stage endometrial cancer (EC). Here, we evaluated the long-term survival of three different approaches of nodal assessment. Methods: This is a multi-institutional retrospective study evaluating long-term outcomes of EC patients having nodal assessment between 01/01/2006 and 12/31/2016. In order to reduce possible confounding factors, we applied a propensity-matched algorithm. Results: Overall, 940 patients meeting inclusion criteria were included in the study, of which 174 (18.5%), 187 (19.9%), and 579 (61.6%) underwent SNM, SNM followed by backup lymphadenectomy (LND) and LND alone, respectively. Applying a propensity score matching algorithm (1:1:2) we selected 500 patients, including 125 SNM, 125 SNM/backup LND, and 250 LND. Baseline characteristics of the study population were similar between groups. The prevalence of nodal disease was 14%, 16%, and 12% in patients having SNM, SNM/backup LND and LND, respectively. Overall, 19 (7.6%) patients were diagnosed with low volume nodal disease. The survival analysis comparing the three techniques did not show statistical differences in terms of disease-free (p = 0.750) and overall survival (p = 0.899). Similarly, the type of nodal assessment did not impact survival outcomes after stratification based on uterine risk factors. Conclusion: Our study highlighted that SNM provides similar long-term oncologic outcomes than LND.
Additional details
Identifiers
- URL
- https://hdl.handle.net/11567/1122079
- URN
- urn:oai:iris.unige.it:11567/1122079
Origin repository
- Origin repository
- UNIGE